One of many 58 knowledge included in the descriptive data, 41 have been circumstances account, one to are an incident collection, thirteen was indeed retrospective cohort degree, several was possible cohort degree, and one is a mix-sectional cohort studies. The female NF1 people which have cancer of the breast came from 23 different places, into almost all her or him originating from the united states from America (38%), Uk (31%), and you may The japanese (12%). Characteristics of them circumstances are demonstrated within the Dining table step one.
Breast cancer stage at time of diagnosis was reported in 54 cases (27 cases of patients < 50 years of age and 27 cases of patients ?50 years of age)
Of the 286 cases identified, 181 reported the age of the patient. Mean age at breast cancer diagnosis was 49.3 years with a median age of 46 years and an interquartile range of 38.3 to 58.0 years. The majority of the patients were < 50 years of age with 53% < 50 years old, 28% between 35 and 44 years old and 15% < 35 years old. Age distribution of the incidence of breast cancer identified in these NF1 cases was evaluated based on their age at the time of diagnosis and revealed a peak age of diagnosis between the ages of 34 to 44 years. 2a).
Detailed analysis regarding breast cancer times claimed. an excellent Many years shipment of the frequency of breast cancer identified from inside the 181 NF1 customers than the SEER databases claimed breast cancer many years distribution out of incident circumstances. b Distribution off breast cancer stage in the lifetime of diagnosis of cancer of the breast recognized inside the 54 NF1 customers. c Ages distribution of your incidence away from cancer of the breast dying known in the 76 NF1 clients as compared to SEER database reported breast cancer age distribution out of deaths
So it occurrence from cancer of the breast cases is actually versus SEER databases for advertised cancer of the breast age shipping off incident times, and that displayed a peak ages of medical diagnosis amongst the age of 55 so you’re able to 64 age on https://datingranking.net/nl/luvfree-overzicht/ general inhabitants (Fig
The type of breast cancer was reported in 110 cases; invasive ductal carcinoma (IDC) was the most commonly reported breast cancer subtype (75.5%). The other 176 breast cancer cases were identified as breast carcinoma. When analyzing all the female NF1 patients with breast cancer, the majority presented with stage I or II disease. However, when separated by age, women < 50 years of age presented with more advanced disease compared to those ?50 years of age (56% vs. 22% stage III-IV, respectively, p = 0.005; Fig. 2b).
Follow-up information was provided in 76 of the reported cases. Mean follow-up time was 44.7 months with a range of 1.9 to 204 months. Nearly half of the reported patients were dead at the time of last follow-up. Mean age at breast cancer death was 45.7 years with a median age of 48.5 years and an interquartile range of 41.3–59.7 years. The majority of the patients were < 50 years of age at time of breast cancer death with 64% < 50 years old, 38% between 35 and 44 years old and 10% < 35 years old. This incidence of breast cancer deaths was compared to the SEER database for reported breast cancer age distribution of deaths, demonstrating a peak age of death between the ages of 55 to 64 years in the general population (Fig. 2c). The relative survival of the female NF1 patients with breast cancer identified in this study was compared to the general population using the SEER database controlling for age and year at diagnosis for each patient (Fig. 3). The median survival for this entire NF1 breast cancer cohort was 5 years compared to the reported median breast cancer survival of over 20 years in the general population using the SEER database. When separated by age, the median survival of the female NF1 patients with breast cancer identified in this study was 5.58 years in those < 50 years of age and over 15 years in those ?50 years of age.